Ninlaro Multiple Myeloma

kyprolis ninlaro multiple myeloma

, otherwise known as carfilzomib, is a proteasome inhibitor. It can be used in combination with low-dose or with Revlimid and low-dose for multiple myeloma patients that have received one to three prior treatments. It can also be used alone for multiple myeloma patients who have relapsed and have received one or more courses of treatment.

Acting as a proteasome inhibitor, blocks the activity of proteasomes, which affects the ability of multiple myeloma cancer cells to grow and survive.

is effective in patients with high-risk myeloma with associated DNA abnormalities; those with a history of previous neuropathy, or nerve problems; and those at an advanced age, ages 65 and up. Patients with reduced kidney functions can safely take .

When taking , patients will experience side effects differently, depending on their health history and the stage of multiple myeloma they are in.

The most common side effects of include:

  • Fatigue
  • Low red blood cell count (anemia)
  • Nausea
  • Low platelet count (thrombocytopenia)
  • Shortness of breath
  • Diarrhea
  • Fever

The more serious side effects of include:

  • Low red blood cell count
  • Low platelet count
  • Low white blood cell count
  • Pneumonia

When combined with Revlimid and , patients may experience different side effects. The most common of these are:

  • Low red cell count
  • Low platelet count
  • Shortness of breath
  • Diarrhea
  • Fatigue

The most common serious side effects of this combination include:

  • Low platelet counts
  • Low red cell count
  • Diarrhea
  • Fatigue

can also cause other serious side effects. These include:

  • Heart complications
  • High blood pressure in the lungs (pulmonary hypertension)
  • Shortness of breath
  • Infusion reactions*
  • Tumor lysis syndrome
  • Liver or kidney toxicity
  • Visual or neurological symptoms
  • May cause harm to a developing fetus

*Patients taking may experience infusion reactions immediately after receiving treatment or up to 24 hours after receiving treatment. The infusion reactions of can include fever, chills, achiness, flushing, facial swelling, vomiting, weakness, shortness of breath, low blood pressure, fainting, chest tightness, and chest pain.

Notify your doctor if you are experiencing any side effects.

Featured image: sciencepics via DepositPhotos

Posted on March 24, 2023